Wednesday, January 18, 2012

CSF profiles and variant dementia

Neurology 2012; 78:47 -54

CSF profiles of tau and abeta are extremely effective differentiating some dementias but not others. Markers were t(total) tau, p (phosphorylated) tau, and Abeta42 in CSF.  " AD profile" of  markers was seen in AD, but also in many autopsy proven cases of  DLB, CBD, FTLD and VaD (about 30-50 % of respective types of dementia patients had :AD profile."  Psychiatric patients and those with subjective complaints of memory loss had normal CSF results.  PSP patients had normal results also.  CJD patients had very high t tau and normal p tau