Neurology 2012; 78:47 -54
CSF profiles of tau and abeta are extremely effective differentiating some dementias but not others. Markers were t(total) tau, p (phosphorylated) tau, and Abeta42 in CSF. " AD profile" of markers was seen in AD, but also in many autopsy proven cases of DLB, CBD, FTLD and VaD (about 30-50 % of respective types of dementia patients had :AD profile." Psychiatric patients and those with subjective complaints of memory loss had normal CSF results. PSP patients had normal results also. CJD patients had very high t tau and normal p tau
CSF profiles of tau and abeta are extremely effective differentiating some dementias but not others. Markers were t(total) tau, p (phosphorylated) tau, and Abeta42 in CSF. " AD profile" of markers was seen in AD, but also in many autopsy proven cases of DLB, CBD, FTLD and VaD (about 30-50 % of respective types of dementia patients had :AD profile." Psychiatric patients and those with subjective complaints of memory loss had normal CSF results. PSP patients had normal results also. CJD patients had very high t tau and normal p tau
