Wednesday, November 13, 2019

APOE e4, white matter hyperintensities and cognition in Alzheimr and Lewy body dementia.

APOE e4, white matter hyperintensities and cognition in Alzheimr and Lewy body dementia.

Mirza ss, SaeedU, Knight J.  Neurology 2019; 93 e1907-1819.

Study with AD Neuroimnaging Initiative phase I.

239 AD patients (167 APOE4 positive)
50 DLB patients

tested white matter hyperintensities burden and cognitive impairment in persons with and without the E4 allele. Certain domain specific cognitive performance was worse in the APOE4 positive individuals.


Lagging C, Lorenten E, Stanne TM, et al.  APOE e4 is associated with younger age at ischemic stroke outset but not with stroke outcome.